Author

Rita T. Brookheart

Washington University in St. LouisORCID 0000-0003-3247-3243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Gretchen A. MeyeriD· 2 shared Meredith O. Kelly· 2 shared Muhammad G. Mousa· 2 shared Shelby Ek· 2 shared Brian N. FinckiD· 1 shared Ella S. Shin· 1 shared Isha SharmaiD· 1 shared Karen C. SheniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Gretchen A. MeyerORCID

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2 papers

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedSep 24, 2025

Site-1 Protease is a negative regulator of sarcolipin promoter activity

Isha Sharma, Meredith O. Kelly, Katelyn Hanners…·Rita T. Brookheart

This study shows that Site-1 Protease (S1P) negatively regulates sarcolipin expression by inhibiting its promoter activity through ATF6 and CREB binding.

DOI 10.1038/s42003-025-08647-y

mousestatistical model

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Molecular BiologyCell ReportsPeer-reviewedMar 31, 2023

Site-1 Protease inhibits mitochondrial metabolism by controlling the TGF-β target gene MSS51

Muhammad G. Mousa, Lahari Vuppaladhadiam, Meredith O. Kelly…·Rita T. Brookheart

This study identifies Site-1 Protease (S1P) as a negative regulator of muscle mass and mitochondrial metabolism by controlling the TGF-β target gene MSS51.

7 citations

mouseexperimental assay

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