Structure and dynamics of a multidomain ligand-gated ion channel revealed under acidic conditions
Olivia Andén, Urška Rovšnik, Marie Lycksell, Marc H. Delarue, Rebecca J. Howard, Erik R. Lindahl
The paper uses cryo-EM, molecular dynamics, and small-angle neutron scattering to characterize an open and closed state of the bacterial ion channel DeCLIC under acidic conditions, revealing structural and dynamic mechanisms of gating.
bioRxiv · Feb 27, 2025 · PreprintBiophysics