Yuxuan Zhuang

The paper identifies a single main-chain hydrogen bond in the β2 subunit M2-M3 linker that inhibits GABAA receptor pore opening and is required to keep the unliganded channel closed.

This study investigates how psychostimulant derivatives modulate the prokaryotic pentameric ligand-gated ion channel sTeLIC through a vestibular pocket, revealing a structure-function mechanism for allosteric potentiation.

The paper reports cryo-EM structures of the calcium-sensitive channel DeCLIC, revealing calcium-binding sites and showing calcium stabilizes the flexible N-terminal domain.

This study uses symmetry-adapted Markov state modeling to analyze conformational transitions in α7 nAChRs, revealing lipid modulation effects and asymmetric transition pathways between functional states.