Marc H. Delarue

The paper presents cryo-EM structures of phage A-family DNA polymerases fused to a uracil-DNA glycosylase domain, revealing their role in reading dU bases and repairing abasic sites during replication.

This study evolves a DNA polymerase into a reverse transcriptase for modified RNA using directed evolution, revealing sequence-to-function relationships through integrated analysis.

This paper evolves a DNA polymerase to synthesize glycosylated xeno-nucleic acids with base and backbone modifications, enabling new chemical functionality in genetic polymers.

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

The paper investigates how DNA polymerases in Paramecium tetraurelia ensure high fidelity during programmed DNA rearrangements by analyzing structural changes in polymerase lambda mutants.

This study investigates how psychostimulant derivatives modulate the prokaryotic pentameric ligand-gated ion channel sTeLIC through a vestibular pocket, revealing a structure-function mechanism for allosteric potentiation.

The paper uses cryo-EM, molecular dynamics, and small-angle neutron scattering to characterize an open and closed state of the bacterial ion channel DeCLIC under acidic conditions, revealing structural and dynamic mechanisms of gating.

This paper introduces a method for template-independent enzymatic RNA synthesis using modified nucleotides and DNA polymerases, enabling the creation of RNA with defined sequences without traditional chemical synthesis limitations.

The paper presents cryo-EM structures of Family-D DNA polymerases in a proofreading mode, revealing a novel correction mechanism and the role of their unique exonuclease domain.

This paper identifies three genes in cyanophage S-2L that enable the synthesis of 2-aminoadenine in bacterial DNA, demonstrating their function in a synthetic system.