Chen Fan

This paper reports cryo-EM structures of human α5β3 GABAARs with modulators, revealing activation mechanisms and differential responses to GABA and etomidate.

This study investigates the gating mechanism of MthK channels using mutants, revealing hydrophobic and lipid-mediated processes that drive channel closure.

This study presents cryo-EM structures of human rho1 GABAA receptors bound to antagonist and agonist drugs, revealing distinct binding poses and conformational changes that explain their pharmacological effects.

This study investigates how psychostimulant derivatives modulate the prokaryotic pentameric ligand-gated ion channel sTeLIC through a vestibular pocket, revealing a structure-function mechanism for allosteric potentiation.

The paper reports cryo-EM structures of the calcium-sensitive channel DeCLIC, revealing calcium-binding sites and showing calcium stabilizes the flexible N-terminal domain.

The paper characterizes the inhibitory mechanisms of two neuroactive steroids at the human {rho}1 GABAA receptor using cryo-EM, electrophysiology, and molecular dynamics simulations.