A keratin bundling transition uncages the nucleus in stretchedepithelia
Tom Golde, Marco Pensalfini, Nimesh R. Chahare, Pere Roca‐Cusachs, Gerhard Wiche, Guillaume Charras, Marino Arroyo, Xavier Trepat
The paper shows that keratin bundling in epithelial cells under stretch allows the nucleus to escape its keratin cage, providing a mechanism for tissue adaptation to mechanical stress.
Nature Physics · Jul 27, 2026Peer-reviewedBiophysics