Pericyte dysfunction alone may be insufficient to drive tick-borne orthoflavivirus NS1-mediated microvascular permeability
Emma Brown, Justin Duruanyanwu, Paola Campagnolo, Kevin Maringer
This study investigates whether NS1 from AHFV and KFDV disrupts microvascular barrier integrity in pericyte-endothelial cell cocultures and finds that pericyte dysfunction alone is insufficient to drive NS1-mediated microvascular permeability.
bioRxiv · Jul 24, 2026 · PreprintMicrobiology