Mark Jeffrey Kohr

This study shows perinatal exposure to heavy metals and their mixtures alters cardiac gene expression, cellular composition, and immune signaling in a sex-specific manner in mice.

This study shows formate reduces ischemic injury in male hearts by increasing protein S-nitrosation and preserving BH4 levels through a NOS-dependent mechanism.

Perinatal exposure of mice to a Pb, As, Cd and Cr(VI) mixture at EPA levels impaired recognition memory, raised anxiety-like behavior, and altered mPFC neuron function.

This study shows GSNOR deletion protects male cardiac function with age but may worsen female cardiac function by removing an age-related SNO imbalance.

This study shows formate reduces ischemic injury in female ADH5-/- hearts but not in intact female or ovariectomized WT hearts, suggesting estrogen-dependent formate utilization in OCM is critical for cardioprotection.

This study shows that gestational arsenic exposure increases postpartum heart size and disrupts calcium handling in cardiomyocytes.