Author

Karen J. Goodrich

Howard Hughes Medical InstituteORCID 0000-0003-3301-7725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

Anne R. GoodingiD· 2 shared Thomas R. CechiD· 2 shared Annette H. ErbseiD· 1 shared Jiarui SongiD· 1 shared John L. RinniD· 1 shared Liqi YaoiD· 1 shared Skylar D. Hanson· 1 shared Taeyoung HwangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Anne R. GoodingORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 23, 2026

RNA-induced PRC2 inhibition depends on the sequence of bound RNA

Jiarui Song, Liqi Yao, Anne R. Gooding…·Thomas R. Cech

This study shows that RNA sequence determines whether it inhibits PRC2 methyltransferase activity by dimerizing the complex or retains its activity by binding monomers.

9 citationstop 1%

humanChIP-seq

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Molecular BiologybioRxivPreprintAug 17, 2023

Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells

Yicheng Long, Taeyoung Hwang, Anne R. Gooding…·Thomas R. Cech

The paper evaluates the RNA-dependence of PRC2 chromatin binding in human pluripotent stem cells using optimized rChIP-seq and mutant analyses, supporting original findings.

11 citations

humanChIP-seq

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