Liqi Yao

This study determines cryo-EM structures of MeCP2 bound to nucleosomes and identifies how RTT mutations affect nucleosome interactions and chromatin targeting.

This study determines the structure of human HIRA with a nucleosome, revealing its active role in a stepwise nucleosome assembly mechanism.

This study shows that RNA sequence determines whether it inhibits PRC2 methyltransferase activity by dimerizing the complex or retains its activity by binding monomers.

The paper designs a cyclic peptide that activates PRC2, leading to increased H3K27 trimethylation and improved stability in mice.