Author

Yicheng Long

Weill Cornell MedicineORCID 0000-0003-3578-5197Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Thomas R. CechiD· 2 shared Alejandro Martin-TrujilloiD· 1 shared Alexia Martínez de PaziD· 1 shared Alistair Nicol BoettigeriD· 1 shared Andreas MaggiD· 1 shared Andrew W. DamaniD· 1 shared Anne R. GoodingiD· 1 shared Aravind R. Gade· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMolecular Biology

Thomas R. CechORCID

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4 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 11, 2025

Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

Alexia Martínez de Paz, Christopher R. Chin, Mythili Ketavarapu…·Steven Zvi Josefowicz

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

1 citation

humanChIP-seq

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Molecular BiologybioRxivPreprintMay 15, 2025

Macromolecular interactions dictate Polycomb-mediated epigenetic repression

Christian Much, Sandy M. Rajkumar, Liming Chen…·Yicheng Long

The paper investigates the distinct roles of PRC2 subcomplexes in epigenetic repression and stem cell differentiation using human pluripotent stem cells.

DOI 10.1101/2025.05.15.654236

humanChIP-seq

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Molecular BiologybioRxivPreprintAug 17, 2023

Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells

Yicheng Long, Taeyoung Hwang, Anne R. Gooding…·Thomas R. Cech

The paper evaluates the RNA-dependence of PRC2 chromatin binding in human pluripotent stem cells using optimized rChIP-seq and mutant analyses, supporting original findings.

11 citations

humanChIP-seq

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedMay 26, 2022

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation

Katerina Kraft, Kathryn E. Yost, Sedona E. Murphy…·Howard Y. Chang

The paper investigates how Polycomb-mediated genome architecture facilitates long-range H3K27 methylation spreading in ESCs and iPSCs, revealing RNA-dependent DNA looping and developmental gene roles in chromatin organization.

110 citationstop 1%

mousehuman

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