Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2
Marina Schrecker, Yeeun Son, Rosa Planells‐Cases, Sumanta Kar, Viktoriia Vorobeva, Uwe Schulte, Bernd Fakler, Thomas J. Jentsch, Richard K. Hite
This study identifies TMEM9 and PI(3,5)P2 as regulators of ClC-3 activity through cryo-EM structures showing TMEM9 blocks Cl- ion flow and PI(3,5)P2 stabilizes their interaction.
bioRxiv · Feb 28, 2025 · PreprintCell Biology