Richard K. Hite

This study identifies SLC33A1 as the major ER GSSG exporter, showing its role in maintaining ER redox balance and protein maturation through direct GSSG transport and regulation of PDIs.

This study investigates how adenine nucleotides potentiate human type 2 IP3R activity by rigidifying the juxtamembrane domain through structural and computational analysis.

The paper uses cryo-EM to study how G4 DNA structures stall replisomes and reveals an inchworm mechanism for DNA translocation.

The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.

This study identifies TMEM9 and PI(3,5)P2 as regulators of ClC-3 activity through cryo-EM structures showing TMEM9 blocks Cl- ion flow and PI(3,5)P2 stabilizes their interaction.

This study reveals the multistep mechanism of PCNA loading by RFC using cryo-EM, showing open and closed PCNA conformations and a revised model for DNA clamp loading.

The paper presents cryo-EM structures of LRRC8A in lipid nanodiscs with DCPIB inhibitor, revealing gating mechanisms and lipid-dependent structural changes.