Author

Amanda J. Brinkworth

University of Nebraska Medical CenterORCID 0000-0003-3340-8494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Dayna McCormick· 1 shared Francis L. Fontanilla· 1 shared Halie SmithiD· 1 shared Holly Black· 1 shared Jaxon J. KrameriD· 1 shared Jeff HamikiD· 1 shared Jose E. PietriiD· 1 shared Joseph R. FauveriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperGenomics

Dayna McCormick

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3 papers

Recent·Most cited

GenomicsMolecular EcologyPeer-reviewedOct 1, 2026

When clades collide: Genomic admixture in blacklegged ticks (Ixodes scapularis) from the Great Plains

Kaylee S. Herzog, Zach Pella, Halie Smith…·Joseph R. Fauver

This study analyzes genomic admixture in Ixodes scapularis ticks from the Great Plains, finding admixed populations in Nebraska with no B. burgdorferi infection, suggesting genomic factors influence Lyme disease transmission.

DOI 10.1111/mec.70577

mousewhole-genome sequencing

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MicrobiologybioRxivPreprintJul 22, 2026

Colonization of 3D-organotypic human skin by the Lyme Disease pathogen, Borrelia burgdorferi

Jaxon J. Kramer, Amanda J. Brinkworth

This study develops a human skin model to study Borrelia burgdorferi colonization, showing peak invasion at 24h and round body formation at 48h, mediated by dermal fibroblasts.

DOI 10.64898/2026.07.20.739593

humanexperimental assay

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MicrobiologymBioPeer-reviewedAug 28, 2024

Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the Type II interferon response of epithelial cells

Francis L. Fontanilla, Joyce A. Ibana, Rey A. Carabeo, Amanda J. Brinkworth

This study shows Chlamydia trachomatis reduces JAK-STAT pathway components to dampen IFN-gamma signaling in epithelial cells.

5 citations

humanbulk RNA-seq

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