Identification and characterization of thiamine analogues with antiplasmodial activity
Imam Fathoni, Terence C. S. Ho, Alex H. Y. Chan, Finian J. Leeper, Kai Matuschewski, Kevin J. Saliba
This study identifies N3-pyridyl thiamine (N3PT) as a more potent antiplasmodial thiamine analogue than oxythiamine, with lower toxicity to human cells and effective in vivo activity against malaria parasites.
Antimicrobial Agents and Chemotherapy · Oct 29, 2024Peer-reviewedPharmacology & Toxicology