Kevin J. Saliba

This study identifies that the Plasmodium falciparum pantothenate kinase complex has a single active site and that Pf14-3-3I is not essential for its activity but may stabilize the complex.

This study develops pantothenamide-mimics with thiazole rings to overcome degradation by pantetheinase, showing potent antiplasmodial activity and enzyme selectivity.

This study identifies N3-pyridyl thiamine (N3PT) as a more potent antiplasmodial thiamine analogue than oxythiamine, with lower toxicity to human cells and effective in vivo activity against malaria parasites.

This study identifies a mutation in the P. falciparum flavokinase gene that confers resistance to roseoflavin and 8-aminoriboflavin by reducing substrate binding affinity.