Author

Vaani Ohri

Harvard UniversityORCID 0000-0003-3344-855XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angeline M. LyoniD· 2 shared Elisabeth E. Garland‐KuntziD· 2 shared Isaac J. FisheriD· 2 shared Kadidia SamassekouiD· 2 shared Kaushik MuralidharaniD· 2 shared Abigail M. Gick· 1 shared Anthony A. KossiakoffiD· 1 shared BernardD. DavisiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Angeline M. LyonORCID

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Author profile →

2 papers

Recent·Most cited

Cryo-EM Structure of Phospholipase Cϵ Defines N-terminal Domains and their Roles in Activity

Kadidia Samassekou, Elisabeth E. Garland‐Kuntz, Vaani Ohri, Isaac J. Fisher, Satchal K. Erramilli, Kaushik Muralidharan, Livia M. Bogdan, Abigail M. Gick, Anthony A. Kossiakoff, Angeline M. Lyon

This study presents the cryo-EM structure of PLCε, revealing its N-terminal domains and their role in membrane engagement and activity.

Communications Biology · Oct 6, 2025Peer-reviewedBiochemistry

RhoA Allosterically Activates Phospholipase Cε via its EF Hands

Vaani Ohri, Kadidia Samassekou, Kaushik Muralidharan, Elisabeth E. Garland‐Kuntz, Isaac J. Fisher, William C. Hogan, BernardD. Davis, Angeline M. Lyon

This study identifies how RhoA activates PLCε through a unique EF hand insertion, enhancing membrane interaction and cardiomyocyte survival during ischemia/reperfusion.

Communications Biology · Sep 26, 2025Peer-reviewedBiochemistry