Author

Isaac J. Fisher

Purdue University West LafayetteORCID 0000-0001-5774-1000Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angeline M. LyoniD· 3 shared Kaushik MuralidharaniD· 3 shared Elisabeth E. Garland‐KuntziD· 2 shared Kadidia SamassekouiD· 2 shared Vaani OhriiD· 2 shared Abigail M. Gick· 1 shared Anthony A. KossiakoffiD· 1 shared Asuka InoueiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

Angeline M. LyonORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivJul 1, 2026

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

Isaac J. Fisher, Kanishka Senarath, Kennedy Outlaw…·Angeline M. Lyon

This study shows Gβγ enhances PLCβ3 activation by reorienting its catalytic site, working with Gq to increase PI(4,5)P2 hydrolysis and Ca2+ release.

DOI 10.7554/elife.110382

𝕏 PostBluesky

BiochemistryCommunications BiologyPeer-reviewedOct 6, 2025

Cryo-EM Structure of Phospholipase Cϵ Defines N-terminal Domains and their Roles in Activity

Kadidia Samassekou, Elisabeth E. Garland‐Kuntz, Vaani Ohri…·Angeline M. Lyon

This study presents the cryo-EM structure of PLCε, revealing its N-terminal domains and their role in membrane engagement and activity.

3 citations

𝕏 PostBluesky

BiochemistryCommunications BiologyPeer-reviewedSep 26, 2025

RhoA Allosterically Activates Phospholipase Cε via its EF Hands

Vaani Ohri, Kadidia Samassekou, Kaushik Muralidharan…·Angeline M. Lyon

This study identifies how RhoA activates PLCε through a unique EF hand insertion, enhancing membrane interaction and cardiomyocyte survival during ischemia/reperfusion.

3 citations

cryo-EMexperimental assay

𝕏 PostBluesky