Angeline M. Lyon

This study shows Gβγ enhances PLCβ3 activation by reorienting its catalytic site, working with Gq to increase PI(4,5)P2 hydrolysis and Ca2+ release.

This study presents the cryo-EM structure of PLCε, revealing its N-terminal domains and their role in membrane engagement and activity.

This study identifies how RhoA activates PLCε through a unique EF hand insertion, enhancing membrane interaction and cardiomyocyte survival during ischemia/reperfusion.