Randy Strich

The paper identifies mitochondrial dysfunction and cyclin C mislocalization as consistent features of MED13L syndrome, linking them to clinical severity and suggesting potential biomarkers.

This study shows cyclin C maintains autophagy-lysosome pathway function in pancreatic development and suppresses cancer by eliminating damaged cells, with potential therapeutic implications for pancreatic neoplasms.

This study shows cyclin C's mitochondrial role in promoting oxidative stress-induced cell death in yeast, independent of its transcriptional function.

The paper introduces an in situ cut-and-paste genome editing method using CRISPR/Cas9 or Cas12a, demonstrating its ability to insert, substitute, and delete sequences in mammalian genomes.

This study shows cyclin C promoter occupancy changes under stress, directing transcriptional reprogramming through CKM movement and activity.