Kathy Qi Cai

NIX-associated mitochondrial remodeling contributes to esophageal epithelial differentiation

This study shows that NIX-mediated mitochondrial remodeling is essential for esophageal epithelial differentiation and that its disruption may contribute to eosinophilic esophagitis.

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

Febuxostat enhances the anti-tumor efficacy of 2-fluoroadenine and 5-methylthioadenosine in MTAP-deleted cancer

The paper shows that adding febuxostat to 2FA and MTA increases their anti-tumor effect in MTAP-deleted cancer by reducing XO activity and increasing 2FAMP levels.

Targeting the Mitochondrial ACSS1 Dependent Acetate and Pyrimidine Axis Suppresses Mantle Cell Lymphoma Progression

This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.

Cyclin C Promotes Pancreatic Development and Suppresses Cancer Initiation Through Maintenance of the Autophagy-Lysosome Pathway

This study shows cyclin C maintains autophagy-lysosome pathway function in pancreatic development and suppresses cancer by eliminating damaged cells, with potential therapeutic implications for pancreatic neoplasms.

Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon

This study identifies P4HA3 and SERPINH1 as key driver genes for collagen production in IntClust-2 breast cancer, showing their role in cell viability, proliferation, and migration, and demonstrates that targeting these genes can reduce tumor growth.

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.