Author

Christoph Humberg

University of MünsterORCID 0000-0003-3394-9338Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

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Daniel KümmeliD· 1 shared Henning D. MootziD· 1 shared Katharina FitzianiD· 1 shared Wolfgang DörneriD· 1 shared Zahide Yilmaz· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiochemistry

Daniel KümmelORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMar 19, 2025

A Cysteine-Less and Ultra-Fast Split Intein Rationally Engineered from Being Aggregation-Prone to Highly Efficient in Protein trans-Splicing

Christoph Humberg, Zahide Yilmaz, Katharina Fitzian…·Henning D. Mootz

The paper identifies aggregation as the cause of low splicing efficiency in a cysteine-less split intein and presents a rationally engineered variant with high activity.

9 citations

protein sequencebiophysical modeling

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