Author

Jennifer Alisa Amrhein

Goethe University FrankfurtORCID 0000-0003-3416-644XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Christian Georg KurziD· 2 shared Stefan KnappiD· 2 shared Susanne MülleriD· 2 shared Theresa Elisabeth Mensing· 2 shared Thomas HankeiD· 2 shared Andreas KrämeriD· 1 shared Benedict‐Tilman BergeriD· 1 shared Christopher LenziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Christian Georg KurzORCID

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2 papers

Recent·Most cited

BiochemistryACS Medicinal Chemistry LettersPeer-reviewedOct 14, 2025

Un-LOK-ing a new approach for conformational selective targeting of STK10 (LOK)

Martina Dettenhöfer, Laura Nadine Tandara, Jennifer Alisa Amrhein…·Thomas Hanke

The paper describes the optimization of a macrocyclic scaffold to develop a selective STK10 inhibitor with nanomolar activity and good kinome selectivity.

3 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryEuropean Journal of Medicinal ChemistryPeer-reviewedAug 22, 2025

Development of pyrazolopyrimidine based macrocyclic kinase inhibitors targeting AAK1

Theresa Elisabeth Mensing, Christian Georg Kurz, Jennifer Alisa Amrhein…·Thomas Hanke

The paper develops pyrazolopyrimidine-based macrocyclic kinase inhibitors targeting AAK1, showing selectivity over related NAK family members and antiviral activity against RNA viruses.

4 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky