Antoine Guyon

The paper shows that the A673T mutation in the APP gene reduces Aβ peptide production in neuroblastoma cells, potentially offering a gene therapy approach for Familial Alzheimer's Disease.

The paper evaluates base editing and PRIME editing techniques to introduce specific mutations in genes associated with Alzheimer's and Duchenne Muscular Dystrophy, assessing their efficiency in cell lines and potential therapeutic impact.

This study demonstrates that SaCas9-mediated deletion restores dystrophin expression in DMD patient-derived myoblasts and in vivo in a mouse model.