Kimia Kamelian

This study shows that elderly individuals vaccinated against SARS-CoV-2 maintain neutralizing antibodies against recent variants, with reduced immune imprinting from ancestral variants after booster doses.

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

The paper identifies a mutation P812S in SARS-CoV-2 associated with immune evasion and upper airway adaptation, but reduced syncytia formation.

V3 primer pools with 22 extra alternates improve coverage; revised library preps raise double-barcode demultiplexing from 42.15% to 74.5%, cut misassignment 35x and bring reagent cost near £10 per sample.