Ian Goodfellow

This paper identifies cereblon (CRBN) as a host factor that promotes influenza virus replication by degrading AMPK, shifting cellular metabolism to support viral growth.

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

This study demonstrates that targeting G3BP1 for proteolysis using PROTACs reduces norovirus replication and prevents cell death.

This study develops an ex vivo model to investigate zoonotic transmission of noroviruses, showing human norovirus can bind and replicate in pig tissue but not chicken tissue.

The paper develops ARTIC HELP, an open-source alternative to ARTIC nanopore sequencing protocols using commercial enzymes, achieving comparable genome coverage for SARS-CoV-2 and Norovirus GII with reduced supply chain dependencies.

This study analyzes within-host SARS-CoV-2 evolution in chronic infections, finding variable rates of evolution and evidence of subpopulation structure.

PrimalScheme provides open-source tools for designing low-cost viral genome sequencing primers, generating over 67,000 schemes and enabling large-scale genomic surveillance.

This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.

This study maps the RNA-RNA interactome of SARS-CoV-2, revealing long-range interactions and conserved structural elements important for viral replication and translation.

V3 primer pools with 22 extra alternates improve coverage; revised library preps raise double-barcode demultiplexing from 42.15% to 74.5%, cut misassignment 35x and bring reagent cost near £10 per sample.

The paper describes the development of a validated SARS-CoV-2 diagnostic workflow in an academic laboratory to support local screening during the pandemic.

This study shows noroviruses suppress host ISG translation by altering eukaryotic initiation factor composition through viral protease and caspase activity.