NeurosciencebioRxivPreprint
Astrocytic μ-δ opioid receptor heterodimers mediate the antidepressant effects of ketamine's metabolite
Shuo Yang, Ling Jun Wang, Y Sun…·Q Zhou
This paper identifies HNK as a compound that targets astrocytic μ-δ opioid receptor heterodimers to mediate antidepressant effects through Gs signaling and CREB activation.
DOI 10.64898/2026.05.31.727553