HJ Xu

SQUALL integrates histology and spatial transcriptomics to enable virtual spatial gene expression profiling and clinical prediction across cancers and platforms.

This paper introduces Tx2Mol, a framework that translates gene-expression signatures into candidate molecules, outperforming baselines in chemical plausibility and phenotypic preservation.

NeoPep designs functional peptides de novo using a deep-learning framework that models biophysical principles, achieving high hit rates and structural accuracy across diverse targets.

This paper identifies HNK as a compound that targets astrocytic μ-δ opioid receptor heterodimers to mediate antidepressant effects through Gs signaling and CREB activation.