Author

Irene Sambri

Istituto di Genetica MolecolareORCID 0000-0003-3500-6958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anna Sorgente· 2 shared Emanuela FranchiniiD· 2 shared Giorgio CasariiD· 2 shared Katarína PAULÍKOVÁ· 2 shared Linda PattiniiD· 2 shared Angelo QuattriniiD· 1 shared Ilaria Marafelli· 1 shared Laura CassinaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Anna Sorgente

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 7, 2026

Berberine improves motor deficits in the spastic paraplegia SPG7 mutant mice

Katarína PAULÍKOVÁ, Anna Sorgente, Emanuela Franchini…·Giorgio Casari

This study shows that berberine improves motor deficits in SPG7 mutant mice by modulating mitochondrial permeability transition pore dynamics.

DOI 10.64898/2026.06.25.734493

mouseexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologyPharmacological ResearchPeer-reviewedMay 7, 2026

Pharmacological Restoration of Mitochondrial Permeability Transition Pore Flickering by High-Content Drug Repurposing

Emanuela Franchini, Matteo Bulloni, Anna Sorgente…·Giorgio Casari

This study identifies berberine as a compound that enhances mitochondrial permeability transition pore flickering, offering a potential therapeutic strategy for disorders like SPG7.

1 citation

humanproteomics

𝕏 PostBluesky