Author

Matthew F. Bush

University of WashingtonORCID 0000-0003-3526-4973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Daniele CanzaniiD· 1 shared Domnița-Valeria RusnaciD· 1 shared Frank DiMaioiD· 1 shared Guangfeng ZhouiD· 1 shared Hahnbeom ParkiD· 1 shared Hai Minh NguyeniD· 1 shared Heike WulffiD· 1 shared Lance J. StewartiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Daniele CanzaniORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 27, 2025

Disorder with consequence: Phosphorylation sites in HSPB5 yield distinct structural outcomes

Natalie L. Stone, Maria K. Janowska, Lucas K Narisawa…·Rachel E. Klevit

This study examines how phosphorylation at different sites in HSPB5 affects its oligomeric structure and function, revealing distinct cellular outcomes based on the extent of phosphorylation.

DOI 10.1101/2025.10.27.684587

protein structureexperimental assay

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedSep 5, 2024

An artificial intelligence accelerated virtual screening platform for drug discovery

Guangfeng Zhou, Domnița-Valeria Rusnac, Hahnbeom Park…·Frank DiMaio

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

283 citationstop 1%

humanstructural biology

𝕏 PostBluesky