Heike Wulff

This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

This study shows that inhibiting KCa3.1 channels reduces neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease models.

This study investigates how Kv1.3 and MAPK14 contribute to microglial oxidative stress and neuroinflammation after organic dust exposure, finding that inhibiting Kv1.3 reduces inflammation and oxidative stress markers.

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

This study evaluates two ligand docking methods for ion channel complexes, finding they can sample near-native poses but struggle to consistently identify them as top-scoring models.