Elizabeth Fidalgo da Silva

This study shows that ERK1/2 signaling modifies Tuberin to disrupt its interaction with Cyclin B1, leading to increased mitotic cells and proliferation.

This study shows that increased Spy1 expression in neural stem cells enhances stemness, reduces differentiation, and promotes oncogenic transformation in mice.

This study examines Tuberin levels during embryonic brain development and finds they decrease in the Purkinje cell layer and during neuronal differentiation.