Lisa Ann Porter

This study shows that ERK1/2 signaling modifies Tuberin to disrupt its interaction with Cyclin B1, leading to increased mitotic cells and proliferation.

This study shows that increased Spy1 expression in neural stem cells enhances stemness, reduces differentiation, and promotes oncogenic transformation in mice.

The paper describes methods to study 3D cell cycle dynamics of glioma stem cells using fluorescent reporter systems and bioinformatics analysis.

This study shows Spy1 promotes mammary stem cell expansion and therapy resistance by overriding cell cycle checkpoints, especially in combination with p53 loss, leading to more aggressive breast cancers.

This study shows that knocking out Spy1 reduces proliferation, metastasis, and stemness in triple negative breast cancer cells and enhances chemotherapy response.

This paper describes methods for generating zebrafish PDX systems to study GSC-mediated tumorigenesis and interactions with the tumor microenvironment.

This study examines Tuberin levels during embryonic brain development and finds they decrease in the Purkinje cell layer and during neuronal differentiation.