David M. Koelle

The paper tracks CMV-specific CD8+ T cells over time to show that clonal diversity and phenotypes are established early and remain stable during chronic infection.

The paper identifies KSHV-specific T-cell receptors in KS tumors, showing they recognize lytic KSHV gene products and could inform immunotherapies.

TCR2HLA infers HLA genotypes from TCR repertoires, enabling identification of immunologically relevant metaclonotypes and discovery of HLA-associated TCRs.

The paper shows that B cells specific for viral oncoproteins in Merkel cell carcinoma tumors predict long-term disease control and enhance T cell responses.

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

The paper identifies KSHV- and HIV-specific T-cells in KS tumors and shows they persist over time and coexist with immunosuppressive macrophages.

The paper introduces a thermodynamically coupled biosensor to rapidly detect neutralizing antibodies against SARS-CoV-2 strains in serum samples.

The paper predicts SARS-CoV-2 B-cell epitopes using computational methods and validates them with ELISA, finding two antigens with high sensitivity and specificity for serological diagnosis of COVID-19.

This study identifies interspecies recombination events in HSV-2 genomes and shows their impact on genetic variation and T-cell recognition.

The paper develops tools to directly sequence HSV genomes from clinical samples with high sensitivity and low viral load, revealing limited evolution during cell culture.

The paper uses next-generation sequencing to analyze copy number variations and interspecies recombination in HHV-6A and HHV-6B reference strains, revealing large tandem repeats and a novel recombinant strain.