Author

Austin Daniel Newsam

University of MiamiORCID 0000-0002-8926-6539Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Francesco MauraiD· 3 shared Abdessamad A. Youssfi· 2 shared Bachisio ZicchedduiD· 2 shared Catalina C Amador· 2 shared Daniel BilbaoiD· 2 shared Dhanvantri ChahariD· 2 shared Frederick Lundry LockeiD· 2 shared Jay Y. SpiegeliD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Francesco MauraORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lymphoma response to chimeric antigen receptor T cell therapy is driven by endogenous tumor-reactive CD8⁺ T cells

Bachisio Ziccheddu, Constanza Savid-Frontera, Venu V.G. Saralamma, Chandler Gatenbee, Abdessamad A. Youssfi, Monika Chojnacka, Meghan A. Menges, Luis Cuadrado-Delgado, Michael A. Durante, John E. Mullinax, Keyla Reid, Julieta Abraham Miranda, Salvatore Corallo, Emily Merritt, W Greg Sawyer, , Frederick Lundry Locke

This study shows that durable CAR-T therapy in lymphoma requires cooperation with endogenous CD8 T cells, and tumors lacking MHC class I or CD58 resist treatment.

bioRxiv · Oct 27, 2026 · PreprintCancer Biology

NRF2 translation block by inhibition of cap-dependent initiation sensitizes lymphoma cells to ferroptosis and CAR-T immunotherapy

Paola Manara, Austin Daniel Newsam, Venu Venkatarame Gowda Saralamma, Tyler Andrew Cunningham, Drew Lazenby, J.J.David Ho, Marco Vincenzo Russo, Abdessamad Youssfi Alaoui, Dhanvantri Chahar, Alicia Bilbao Martinez, Nikolai S. Fattakhov, Alexandra Marie Carbone, Olivia Barbara Farag, Alexa Marie Barroso, Kyle S. Hoffman, , Jonathan Harry Schatz

This study shows that inhibiting cap-dependent translation in lymphoma cells increases sensitivity to ferroptosis and CAR-T therapy by reducing NRF2 expression.

Cancer Research · Jul 31, 2025Peer-reviewedCancer Biology

RHOA Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant B-Cell Lymphoma

Austin Daniel Newsam, Bachisio Ziccheddu, Abdessamad A. Youssfi, Venu Venkatarame Gowda Saralamma, Yitzhar E. Goretsky, Isaiah Sheffield-Veney, Paola Manara, Daniel E Tsai, Adithi Jeevan, Santiago Foos-Russ, David M. Suissa, Marco Vincenzo Russo, Nikolai S. Fattakhov, David Carmona-Berrio, Natalia Campos Gallego, , Jonathan Harry Schatz

bioRxiv · Feb 27, 2025 · PreprintCancer Biology