Generation of ordered protein assemblies using rigid three-body fusion
Ivan Vulovic, Qing Yao, Young‐Jun Park, Alexis Courbet, Andrew S. Norris, Florian Büsch, Aniruddha Sahasrabuddhe, Hannes Merten, Danny D. Sahtoe, George Ueda, Jorge A. Fallas, Sara J. Weaver, Yang Hsia, Robert A. Langan, Andreas Plückthun, , David A. Baker
The paper introduces a computational method for designing rigid protein assemblies through three-body fusion and validates it experimentally with mass spectrometry and cryo-EM.
Proceedings of the National Academy of Sciences · May 31, 2021Peer-reviewedSynthetic Biology