Author

George Ueda

University of WashingtonORCID 0000-0002-9792-7149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein design· 3 Assay:protein structure· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

David A. BakeriD· 4 shared David VeesleriD· 4 shared Young‐Jun ParkiD· 4 shared Adam P. MoyeriD· 2 shared Alexis CourbetiD· 2 shared Jorge A. FallasiD· 2 shared Neil P. KingiD· 2 shared Scott E. BoykeniD· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersSynthetic Biology

David A. BakerORCID

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Author profile →

4 papers

Recent·Most cited

Computational design of nanoscale rotational mechanics in de novo protein assemblies

Alexis Courbet, Jesse M. Hansen, Yang Hsia, Neville P. Bethel, Young‐Jun Park, Chunfu Xu, Adam P. Moyer, Scott E. Boyken, George Ueda, Una Nattermann, Deepesh Nagarajan, Daniel‐Adriano Silva, William Sheffler, Joel D. Quispe, Ashley L. Nord, , David A. Baker

This paper computationally designs self-assembling protein rotary machines that sample internal rotational degrees of freedom based on energy landscapes.

Science · Apr 21, 2022Peer-reviewedSynthetic Biology

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

Andrew C. Hunt, James Brett Case, Young‐Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Andy Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, , David A. Baker

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

Science Translational Medicine · Apr 12, 2022Peer-reviewedSynthetic Biology

Generation of ordered protein assemblies using rigid three-body fusion

Ivan Vulovic, Qing Yao, Young‐Jun Park, Alexis Courbet, Andrew S. Norris, Florian Büsch, Aniruddha Sahasrabuddhe, Hannes Merten, Danny D. Sahtoe, George Ueda, Jorge A. Fallas, Sara J. Weaver, Yang Hsia, Robert A. Langan, Andreas Plückthun, , David A. Baker

The paper introduces a computational method for designing rigid protein assemblies through three-body fusion and validates it experimentally with mass spectrometry and cryo-EM.

Proceedings of the National Academy of Sciences · May 31, 2021Peer-reviewedSynthetic Biology

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

George Ueda, Aleksandar Antanasijevic, Jorge A. Fallas, William Sheffler, Jeffrey Copps, Daniel Ellis, Geoffrey B. Hutchinson, Adam P. Moyer, Anila Yasmeen, Yaroslav Tsybovsky, Young‐Jun Park, Matthew J. Bick, Banumathi Sankaran, Rebecca A. Gillespie, Philip J. M. Brouwer, , David A. Baker

Designed trimers matched to viral glycoprotein termini yielded tetrahedral, octahedral and icosahedral nanoparticles with cryo-EM-verified structures that display native-like HIV Env, influenza HA and RSV F.

eLife · Aug 3, 2020Peer-reviewedSynthetic Biology✦ In-depth digest