Author

Joana Catarina Macedo

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do PortoORCID 0000-0003-3578-9120Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Carlos Sousa-SoaresiD· 1 shared Elsa LogarinhoiD· 1 shared José Pedro CastroiD· 1 shared Marcos Antonio Barbosa Da SilvaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperCell Biology

Carlos Sousa-SoaresORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintOct 29, 2025

FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers

Carlos Sousa-Soares, Marcos Antonio Barbosa Da Silva, José Pedro Castro…·Elsa Logarinho

This study shows that restoring FOXM1 activity in aged cells reduces DNA damage and epigenetic changes, inhibiting senescence enhancers and offering a therapeutic approach to aging.

DOI 10.1101/2025.10.29.685369

humanDNA methylation

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