Carlos Sousa-Soares

This study shows that restoring FOXM1 activity in aged cells reduces DNA damage and epigenetic changes, inhibiting senescence enhancers and offering a therapeutic approach to aging.

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

This study shows a small-molecule agonist of KIF2C enhances DNA repair and mitigates aging phenotypes in progeria and Down syndrome models.