José Pedro Castro

An inflammatory gene set driven epigenetic clock tracks down disease progression and rejuvenation

This paper develops an inflammation-driven epigenetic clock to track disease progression and rejuvenation using DNA methylation data.

FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers

This study shows that restoring FOXM1 activity in aged cells reduces DNA damage and epigenetic changes, inhibiting senescence enhancers and offering a therapeutic approach to aging.

Transcriptomic entropy reveals tissue-specific patterns in aging and predicts cancer progression

This study examines transcriptomic entropy in aging and cancer, finding tissue-specific entropy changes and its association with cancer progression and survival outcomes.

Molecular signatures of longevity identify compounds that extendmouse lifespan and healthspan

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging research

The paper identifies a Niemann-Pick type C mouse model with accelerated brain aging as a novel model for Alzheimer's disease research by analyzing transcriptomic data from congenital diseases.

Rapamycin treatment during development extends lifespan and healthspan

Rapamycin treatment during early life extends lifespan and healthspan in mice and Daphnia magna by slowing development and delaying aging.