Steven M. Dubinett

The paper introduces FORGE-KI, a modular framework for endogenous knock-in engineering that supports multiple repair pathways and provides software for automated design.

The paper introduces FORGE-CRISPR, a system for constructing CRISPR libraries using modular components, enabling flexible and reusable library generation for functional genomics studies.

This study identifies four molecular archetypes of lung adenocarcinoma premalignant lesions using bulk RNA and exome sequencing, linking proliferation-associated features to aggressive tumor outcomes.

This study shows dietary α-Ketoglutarate reduces lung adenocarcinoma in female mice by altering histone marks and TBX5 expression, while increasing tumor growth in males and modulating the immune microenvironment.

This paper introduces cfSNV, a somatic SNV caller for cfDNA that outperforms existing tools in detecting low-frequency mutations and applies it to immunotherapy prognosis in non-small-cell lung cancer.

The paper analyzes single-cell RNA-seq data to identify ACE2 expression patterns in human lung epithelial cells, finding high ACE2 expression in alveolar type II cells and co-expression with pathogen receptors.

The paper evaluates reference samples for genome-scale miRNA profiling and develops metrics and an online pipeline to assess measurement performance.