Lin Hai Tian

This study identifies Esm1 as a target for normalizing dysfunctional vessels in liver metastasis by showing its role in capillary tip cells and its correlation with poor prognosis.

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

The paper shows that blocking monocytes alone is insufficient to reduce LMAMs, as KCs can replenish them through proliferation or infiltration, and their reprogramming contributes to immunosuppression.