Author

Ryan Takahashi

Denali Therapeutics (United States)ORCID 0000-0003-1016-0633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Anthony A. EstradaiD· 2 shared Connie HaiD· 2 shared Ernie YulyaningsihiD· 2 shared Thomas SandmanniD· 2 shared Alicia A. Nugent· 1 shared Amy W-S Leung· 1 shared Anna I. BakardjieviD· 1 shared Audrey Gill· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Anthony A. EstradaORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 6, 2025

CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity

Jing Guo, Tomás P. Bachor, Ryan Takahashi…·Ernie Yulyaningsih

TN-783, a CNS-penetrant NLRP3 inhibitor, induces sustained weight loss and reverses hypothalamic inflammation in diet-induced obese mice.

1 citation

mouseproteomics

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NeuroscienceeLifePeer-reviewedNov 14, 2023

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

Ernie Yulyaningsih, Jung H. Suh, Melania H. Fanok…·Pascal E. Sanchez

DNL343 reduces neurodegeneration in mouse models by inhibiting the integrated stress response and normalizing dysregulated biomarkers, with potential clinical relevance for vanishing white matter disease.

11 citations

mouseexperimental assay

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