Teresa Ezponda

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

This study uses single-cell RNA sequencing to analyze changes in hematopoietic stem and progenitor cells during aging and myeloid malignancies, identifying altered gene expression and regulatory networks.

The paper introduces SimiC, a method for inferring gene regulatory networks per cell phenotype and comparing them across conditions, revealing regulatory dynamics missed by single GRN approaches.