Katarzyna Karolina Pels

The paper introduces a tri-omic method to study 3D epigenome and transcriptome dynamics in brain cells across mouse lifespan, revealing distinct genomic mechanisms in neurons and non-neuronal cells.

The paper investigates the relationship between Bdnf transcription and histone acetylation in epilepsy, finding that Bdnf repositioning correlates with epileptic traits and is influenced by transcriptional activity and histone deacetylase inhibition.

This paper develops a new electron microscopy method to visualize 3D chromatin folding at ultra-resolution in human cells and finds high heterogeneity in chromatin structures.