Liuhan Dai

FINDER enables attomolar biomarker detection by converting kinetic fingerprinting into area-scalable sensitivity without amplification.

The paper quantifies VCP hexamer assembly and subunit exchange dynamics, showing that the R155H mutation impairs ASPL-mediated exchange, potentially stabilizing mutant VCP in assemblies.

This paper introduces Bio-SCOPE, a platform that detects multiple biomarkers with high sensitivity and specificity, demonstrating its application in detecting miRNAs and proteins in disease contexts.

This paper develops an amplification-free method to quantify DNA methylation at the BCAT1 promoter with high sensitivity and specificity, enabling improved early detection of methylated cancer DNA biomarkers.

This study measures MBD1 binding kinetics to methylated DNA with varying patterns and structural motifs, revealing that tandem CpG sites and DNA forks enhance binding, leading to a mechanistic model of epigenetic boundary maintenance.