Alice A. Burchett

This study shows that microgravity-grown GBM organoids exhibit enhanced transcriptomic, proteomic, and architectural features associated with worse patient outcomes compared to ground controls.

The paper shows mechanical compression causes neuronal apoptosis, synaptic loss, and glial inflammation in GBM models, revealing pathways for neuroprotection.

This study shows chronic compression transforms macrophages into a pro-tumor state, resembling glioma-associated macrophages, independent of tumor cell factors.

This study shows macrophages generate mechanical stress in agarose gels and respond to environmental stiffness and cytokine signals.

This study simulates how brain tumor mechanical forces affect glymphatic transport in the brain parenchyma, showing increased stress and strain reduce CSF flow rates.

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.