Julian Najera

Multi-omics and spatial analysis of microgravity-grown glioblastoma organoids reveals superior modeling of advanced disease after long-term spaceflight

This study shows that microgravity-grown GBM organoids exhibit enhanced transcriptomic, proteomic, and architectural features associated with worse patient outcomes compared to ground controls.

Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans

The paper shows mechanical compression causes neuronal apoptosis, synaptic loss, and glial inflammation in GBM models, revealing pathways for neuroprotection.

Chronic compression drives macrophages toward a pathological pro-tumor state

This study shows chronic compression transforms macrophages into a pro-tumor state, resembling glioma-associated macrophages, independent of tumor cell factors.

Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast cancer peritumoral microenvironments

This study uses instant FLIM to show that mechanical compression of stromal cells in breast cancer models alters their metabolism, with distinct effects on fibroblasts and adipocytes, validated by transcriptomics and mitochondrial analysis.