Shailza Singh

This paper develops a mathematical model to explore how IL-6 signaling disrupts BCAA metabolism and redox homeostasis, contributing to NSCLC-induced sarcopenia.

This study identifies SH3PXD2B's role in promoting breast cancer lung metastasis through epithelial-to-mesenchymal transition, using RNA sequencing, functional experiments, and imaging.

The paper uses single cell ATAC sequencing to study cytokine reciprocity in L. major infected macrophages, identifying a transient state called sleepy macrophages regulated by NFAT5.

The paper investigates the role of SOCS1/SOCS3 immune axis in modulating IL6 signaling during Leishmanial infection and proposes a synthetic biology approach to restore pro-inflammatory cytokine expression.

This paper explores the structural evolution of the complement system in Leishmaniasis using computational modeling to address challenges in GPCR structural analysis.

The paper uses mathematical characterization and flux balance analysis to identify key metabolites and enzymes in Leishmania's metabolic network, highlighting GLOI as a potential therapeutic target.

The paper develops a feed forward multilayer perceptron model for diagnosing leishmaniasis using genetic datasets, achieving 85.71% accuracy.

The paper investigates the role of the ATG9-PI3P negative feedback loop in regulating autophagy during Leishmania major infection.

The paper models how stochastic variations in a transcription factor target gene network affect cytokine response dynamics in leishmaniasis using a synthetic circuit with negative feedback.