Structural sequence evolution and Computational Modeling Approaches of the Complement System in Leishmaniasis

The complement system acts as central arm of innate immunity that is critical to host defense as well as the development of adaptive immunity. The origins of the complement system have so far been traced, which correlates to near to the beginnings of multi-cellular animal life. Owing to the difficulty in obtaining crystal structures of GPCRs in either inactive or active state, accurate structural modeling is still highly desirable for the majority of GPCRs. In an attempt to dissect the conformational changes associated with GPCR activation, computational modeling approaches is being pursued in this paper along with the evolutionary divergence to deal with the structural variability.